Glutamate Receptor 1 Antikörper (pSer845)

Produktnummer ABIN361477

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Glutamate Receptor 1 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Ratte und wurde in 26+ Publikationen erwähnt.

Kurzübersicht für Glutamate Receptor 1 Antikörper (pSer845) (ABIN361477)

Target: Glutamate Receptor 1 (GLUR1)

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutamate Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Glutamate Receptor 1 Antikörper

Bindungsspezifität: pSer845

Spezifität: Specific for endogenous levels of the ~100 kDa GluR1 protein phosphorylated at Ser845. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Kreuzreaktivität: Maus, Ratte

Homologie: human, non-human primates

Produktmerkmale: Our GluR1-Subunit (Ser845) rabbit polyclonal phosphospecific primary antibody is produced in-house. It detects GluR1-Subunit (Ser845) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB, IHC.

Aufreinigung: Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser845 of rat GluR1, conjugated to keyhole limpet hemocyanin (KLH).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Dilution Range: WB Brain: 1:1000

Dilution Range: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-Glutamate Receptor 1 Antikörper (ABIN361477)

Hikida, Morita, Kuroiwa, Macpherson, Shuto, Sotogaku, Niwa, Sawa, Nishi: "Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice." in: Neuroscience research, Vol. 151, pp. 38-45, (2020) (PubMed).

Mao, Wang: "Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain." in: Brain and behavior, Vol. 10, Issue 3, pp. e01543, (2020) (PubMed).

Musante, Li, Kanyo, Lam, Colangelo, Cheng, Brody, Greengard, Le Novère, Nairn: "Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition." in: eLife, Vol. 6, (2018) (PubMed).

Hollis, Sevelinges, Grosse, Zanoletti, Sandi: "Involvement of CRFR1 in the Basolateral Amygdala in the Immediate Fear Extinction Deficit." in: eNeuro, Vol. 3, Issue 5, (2017) (PubMed).

Zhang, Fu, Fu, Ip: "S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength." in: Nature communications, Vol. 6, pp. 8665, (2016) (PubMed).

Ip, Fu, Cheng, Tong, Lok, Liang, Ye, Ip: "Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 40, Issue 8, pp. 1877-87, (2015) (PubMed).

Mao, Xue, Jin, Wang: "Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine." in: Journal of neurochemistry, Vol. 133, Issue 6, pp. 795-805, (2015) (PubMed).

Suzuki, Harada, Shiraishi, Kimura: "In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 471-9, (2015) (PubMed).

Tassin, Benavides, Plattner, Nishi, Bibb: "Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain." in: The Journal of biological chemistry, Vol. 290, Issue 26, pp. 16319-29, (2015) (PubMed).

Mao, Hastings, Fibuch, Wang: "Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice." in: European journal of pharmacology, Vol. 738, pp. 237-44, (2014) (PubMed).

Wang, Zhang, Xu, Zhu, Wang, He, Zhang, Guo, Kong, Huang, Li: "Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice." in: Current Alzheimer research, Vol. 11, Issue 7, pp. 672-80, (2014) (PubMed).

Bernard, Castano, Bayer, Benke: "Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures." in: Neuropharmacology, Vol. 84, pp. 1-12, (2014) (PubMed).

Xue, Edwards, Mao, Guo, Jin, Fibuch, Wang: "Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration." in: Neurochemistry international, Vol. 64, pp. 48-54, (2013) (PubMed).

Shen, Fu, Cheng, Fu, Ip: "Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 2, pp. 464-72, (2013) (PubMed).

Davis, Olausson, Greengard, Taylor, Nairn: "Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits." in: The European journal of neuroscience, Vol. 35, Issue 2, pp. 300-8, (2012) (PubMed).

Ferrario, Loweth, Milovanovic, Wang, Wolf: "Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens." in: Neuroscience letters, Vol. 490, Issue 3, pp. 180-4, (2011) (PubMed).

Kuroiwa, Snyder, Shuto, Fukuda, Yanagawa, Benavides, Nairn, Bibb, Greengard, Nishi: "Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex." in: Psychopharmacology, (2011) (PubMed).

Torres-Altoro, Mathur, Drerup, Thomas, Lovinger, OCallaghan, Bibb: "Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum." in: Journal of neurochemistry, Vol. 119, Issue 2, pp. 303-13, (2011) (PubMed).

Ferrario, Loweth, Milovanovic, Ford, Galiñanes, Heng, Tseng, Wolf: "Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²?-permeable AMPA receptors during the incubation of cocaine craving." in: Neuropharmacology, Vol. 61, Issue 7, pp. 1141-51, (2011) (PubMed).

Sears, Liu, Narayanan, Sharf, Yeckel, Laubach, Aghajanian, DiLeone: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).

Details zu Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Andere Bezeichnung: GRIA1

Hintergrund:

Synonyms: GLUR 1 antibody, GLUR A antibody, AMPA 1 antibody, AMPA selective glutamate receptor 1 antibody, AMPA-selective glutamate receptor 1 antibody, GluA1 antibody, GLUH1 antibody, GluR K1 antibody, GluR-1 antibody, GluR-A antibody, GluR-K1 antibody, GLUR1 antibody, GLURA antibody, GluRK1 antibody, Glutamate receptor 1 antibody, Glutamate receptor ionotropic AMPA 1 antibody, Glutamate receptor ionotropic antibody, Glutamate receptor, ionotropic, AMPA 1 antibody, Gria1 antibody, GRIA1_HUMAN antibody, HBGR1 antibody, MGC133252 antibody, OTTHUMP00000160643 antibody, OTTHUMP00000165781 antibody, THUMP00000224241 antibody, OTTHUMP00000224242 antibody, OTTHUMP00000224243 antibody

Description Logic: Our GluR1-Subunit (Ser845) rabbit polyclonal phosphospecific primary antibody is produced . It detects GluR1-Subunit (Ser845) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB, IHC.

Gene Name Alternatives: GRIA1

Molekulargewicht: 100 kDa

Gen-ID: 50592

UniProt: P19490

Pathways: PI3K-Akt Signalweg